Every peptide.Every study.Graded.

A peptide is a short chain of amino acids — the same building blocks that make up proteins, just in a smaller sequence (typically 2 to 50 amino acids). Many peptides are signaling molecules the body produces naturally; others are synthetic analogs designed to mimic, block, or modify those signals.

Each peptide is graded against six weighted sub-scores for every outcome: mechanism understood, count and quality of human studies, effect vs placebo, long-term safety data, side effect profile, regulatory status. Sub-scores roll up into a letter grade A–F.

Independence. The moment a publication sells what it reviews, every grade becomes suspect. Peptigrade is funded by member subscriptions and institutional licenses — no supplement sales, no sponsorships, no affiliate revenue.

It depends on the peptide and the jurisdiction. Some are FDA-approved drugs. Some are sold legally for research use only. Some are banned in competitive sports by WADA. Each peptide page includes its current regulatory status.

Because the evidence is different for each use. BPC-157 has strong animal evidence for tendon healing but no randomized human trial — that earns a C. Semaglutide has ten Phase 3 RCTs for type 2 diabetes — that earns an A.

Whenever new high-quality evidence is published. We monitor PubMed, ClinicalTrials.gov, and major journals for new peptide studies. When a new RCT or systematic review materially changes the evidence base, we re-grade the page.

No. Peptigrade publishes evidence summaries for educational purposes. Nothing on this site recommends that any specific person take any specific peptide. Consult a licensed medical professional before making any health decision.