§ PG.INDEX · 40 GRADED

Every peptide
we’ve graded.

Browse the complete Peptigrade index. Each entry shows the top-outcome grade, total studies indexed, and current regulatory status. Click any row to see the full evidence breakdown.

HCG

Human Chorionic Gonadotropin — 237-amino-acid α/β heterodimeric glycoprotein hormone (~36.7 kDa)

Ovulation induction in assisted reproductive technology (ART)

Strong

Reproductive & Endocrine

533
8

IGF-1

Insulin-like Growth Factor 1 — 70-amino-acid single-chain polypeptide (recombinant human mecasermin is the FDA-approved form; IGF-1 LR3 is a synthetic long-R3 analog with Arg3→Glu and a 13-residue N-terminal extension)

Severe primary IGF-1 deficiency (pediatric growth failure)

Strong

Growth & Metabolic

57
8

Methylene Blue

Methylthioninium chloride — 3,7-bis(dimethylamino)phenothiazin-5-ium chloride

Acquired methemoglobinemia (IV, prescription)

Strong

Cognitive & Mood

127
7

Oxytocin

Oxytocin — cyclic nonapeptide Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide Cys1-Cys6)

Labor induction & augmentation

Strong

Neuroendocrine & Social Cognition

455
8

Semaglutide

GLP-1 receptor agonist

Type 2 diabetes

Strong

Metabolic & Weight

332
6

Tesamorelin

Tesamorelin acetate — N-[(3E)-1-oxo-3-hexen-1-yl]-GHRH(1-44), a trans-3-hexenoyl-modified 44-amino-acid human GHRH analog

HIV-associated lipodystrophy — visceral fat reduction

Strong

Growth Hormone Axis

25
7

Tirzepatide

Dual GIP / GLP-1 receptor agonist

Obesity

Strong

Metabolic & Weight

173
5

Vitamin B-12

Cobalamin — cobalt-containing corrinoid cofactor (cyanocobalamin, methylcobalamin, hydroxocobalamin, adenosylcobalamin)

Treatment of pernicious anemia and B12-deficiency megaloblastic anemia

Strong

Nutraceutical

125
8

Cagrilintide

Cagrilintide — long-acting amylin analog (C20 fatty-acid–acylated, 37 aa)

Obesity (combined with semaglutide as CagriSema)

Promising

Metabolic & Weight

18
6

CJC-1295

CJC-1295 with Drug Affinity Complex — albumin-binding GHRH(1-29) analog, [D-Ala², Gln⁸, Ala¹⁵, Leu²⁷]-GHRH(1-29)-Lys³⁰-Nε-maleimidopropionyl

Sustained GH and IGF-1 elevation

Promising

Growth Hormone Axis

16
7

Glutathione

L-Glutathione (reduced) — γ-L-glutamyl-L-cysteinyl-glycine

Restoration of GSH and oxidative-stress biomarkers in deficient populations (oral precursor supplementation)

Promising

Endogenous antioxidant / detoxification

45
8

Ipamorelin

Selective growth hormone secretagogue

GH secretion

Promising

Growth Hormone Axis

46
4

Kisspeptin-10

Kisspeptin-10 (KP-10) — C-terminal decapeptide of metastin, H-YNWNSFGLRF-NH₂

Diagnostic GnRH/LH-axis testing in hypogonadotropic hypogonadism

Promising

Reproductive & Endocrine

45
7

NAD+

β-Nicotinamide adenine dinucleotide (oxidized form) — C21H27N7O14P2, MW 663.43 Da

Raising whole-blood / skeletal-muscle NAD+ with oral NR in deficient or older adults (biomarker endpoint)

Promising

Longevity & Aging

38
8

Ostarine (MK-2866)

Enobosarm — (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Lean body mass in cancer cachexia and sarcopenic populations

Promising

SARM

38
8

PT-141

Bremelanotide

Hypoactive sexual desire disorder (HSDD)

Promising

Sexual Health

51
3

Sermorelin

Sermorelin acetate — GHRH(1-29)-NH₂, synthetic growth-hormone-releasing-hormone analog

Diagnostic provocation for pediatric growth hormone deficiency

Promising

Growth Hormone Axis

21
7

SS-31 (Elamipretide)

Elamipretide — Szeto-Schiller tetrapeptide D-Arg-Dmt-Lys-Phe-NH₂

Barth syndrome

Promising

Mitochondrial

31
7

Tesofensine

NS2330 — phenyltropane triple monoamine (NE/DA/5-HT) reuptake inhibitor

Obesity (BMI ≥30)

Promising

Metabolic & Weight

34
7

BPC-157

Body Protection Compound 157 — pentadecapeptide GEPPPGKPADDAGLV

Tendon healing

Mixed

Recovery & Repair

154
7

GHK-Cu

Copper tripeptide-1

Wound healing (topical)

Mixed

Recovery & Repair

69
4

Melanotan II

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 — cyclic heptapeptide α-MSH analog

Skin tanning / melanogenesis

Mixed

Pigmentation & Melanocortin

50
7

MK-677 (Ibutamoren)

Ibutamoren — orally-active non-peptide ghrelin/GHSR-1a agonist (spiroindoline small molecule, MW 528.67 free base)

GH / IGF-1 elevation (pharmacodynamic)

Mixed

Growth Hormone Axis

49
8

MOTS-c

Mitochondrial Open Reading Frame of the 12S rRNA Type-c — 16-aa peptide MRWQEMGYIFYPRKLR

Insulin sensitivity & metabolic homeostasis

Mixed

Metabolic & Longevity

47
7

RAD-140 (Testolone)

RAD-140 — 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile (Vosilasarm, EP0062)

AR+/ER+ metastatic breast cancer (monotherapy)

Mixed

SARM

30
6

Retatrutide

Triple GIP / GLP-1 / glucagon receptor agonist (LY3437943)

Obesity / chronic weight management

Mixed

Metabolic & Weight

8
5

Selank

Selank — heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin + C-terminal Pro-Gly-Pro)

Generalized anxiety disorder

Mixed

Anxiolytic & Nootropic

25
7

Semax

Heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro — synthetic analog of ACTH(4-7) with C-terminal Pro-Gly-Pro extension

Acute ischemic stroke (adjunctive treatment)

Mixed

Nootropic & Neuroprotective

49
7

SNAP-8

Acetyl Octapeptide-3 — Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂

Fine-line / wrinkle depth reduction (topical)

Mixed

Cosmetic & Skin

13
6

TB-500

Thymosin β-4 (synthetic fragment)

Soft tissue repair

Mixed

Recovery & Repair

68
4

Thymalin

Thymalin — bovine thymus polypeptide complex (mixture of short immunomodulatory peptides including Glu-Trp (EW), Lys-Glu (KE), and EDP)

Adjunctive immunomodulation in severe COVID-19 in older adults

Mixed

Immune Modulation & Geroprotection

38
7

5-Amino-1MQ

5-Amino-1-methylquinolinium (small-molecule NNMT inhibitor)

Diet-induced obesity / body-weight reduction

Weak

Metabolic & Weight

14
6

AOD-9604

Anti-Obesity Drug 9604 — Tyr-hGH(177-191), a 16-amino-acid synthetic fragment of human growth hormone (sequence YLRIVQCRSVEGSCGF) with an N-terminal tyrosine addition and a Cys7-Cys14 intramolecular disulfide bond

Body weight / fat-mass reduction in adults with obesity

Weak

Growth Hormone Axis — Fragment

24
8

BAM15

N5,N6-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

Diet-induced obesity / weight loss

Weak

Metabolic & Weight

18
6

DSIP

Delta Sleep-Inducing Peptide — nonapeptide WAGGDASGE

Sleep quality in chronic insomnia

Weak

Sleep & Stress

32
7

Epitalon

Epitalon — tetrapeptide Ala-Glu-Asp-Gly (AEDG)

Telomerase activation & telomere elongation (in vitro / ex vivo)

Weak

Longevity & Telomere

28
8

Fragment 176-191

Human growth hormone C-terminal fragment 176-191 (hGH 176-191) — sequence FLRIVQCRSVEGSCGF

Fat loss / lipolysis

Weak

Metabolic & Body Composition

20
6

Lipo-C

Lipotropic injection (MIC) — methionine + inositol + choline, typically with cyanocobalamin (B12) and variable B-complex (B1/B2/B5/B6)

Weight loss / fat loss

Weak

Metabolic & Weight

18
6

PEG-MGF

PEGylated Mechano Growth Factor — IGF-1Ec C-terminal E-domain peptide (YQPPSTNKNTKSQRRKGSTFEEHK) conjugated to polyethylene glycol

Satellite cell activation & muscle repair

Weak

Growth Factor

17
6

SLU-PP-332

(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide — synthetic pan-agonist of estrogen-related receptors ERRα/β/γ (MW 290.32 g/mol, C₁₈H₁₄N₂O₂)

Exercise capacity / endurance in humans

Weak

Metabolic & Weight

8
6